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Apart from chitosan, several other polymers, such as polyamidoamine, carbopol, PEG, poly( acrylic acid), poly-L-lysines, protamine, histone, polycationic dextrans, starch and saponins, have actually been discovered for the administration of healthy protein medicines through the nasal path [13, 41, 55] In terms of saponins, Sajadi Tabassi et al. revealed that nasal solutions including ATS (1% w/v) drawn out from the origin of Acanthophyllum squarrosum were more efficient than QTS and SC in advertising insulin absorption through the nasal route [55] Medication service providers doing not have favorable fee, like starch, can present shorter half-times of clearance in the human nasal dental caries [53] The enhanced efficacy in nasal drug absorption has actually been recommended to be associated with the extraction of water from the nasal environment or modifications in the expression of tight junction proteins, forcing the opening of limited junctions in the paracellular pathway [52] Although these polymers could prolong drug release and advertise continual therapeutic effects, restraints associated with minimized medication organic task and mucociliary clearance have actually been related to the application of these polymers in nasal formulations [56]<br>Significantly, upon intranasal administration, insulin can get in the systemic circulation and traverse both the blood-brain obstacle (BBB) and the blood-cerebrospinal fluid obstacle (BCSFB). 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